- 18 July 1961 - Decision of the state parliament of North Rhine-Westphalia in favor of Bochum as the site of a new university
- May 1962 - Presentation of a draft of the structural plans (research and teaching in 18 departments) by the founding committee for Bochum University - In December, the "Empfehlungen zum Aufbau der Universität Bochum" (Recommendations for the Structure of Bochum University) are published
- 17/04/1963 - Appointment of the first professor
- 29/30 April 1965 - 6th meeting of the hitherto appointed professors: Election of the first rector as well as the deans, senators and spokespersons of the departments, constitution of the senate
- 30/06/1965 - Ceremonial opening of the University
- 02/11/1965 - Commencement of teaching in the humanities and social sciences departments as well as in individual natural science departments
- 01/10/1967 - Integration of the Essen Clinic into the RUB (until 1972; previously: Clinic II of the University of Münster)
- 25/06/1969 - Resolution of the "Konvent" on a new constitution - the RUB receives a Rectorate as the governing body and a university parliament with quarterly equal representation as the "organ of lawmaking"
- 01/10/1975 - Establishment of "Unikontakt" (contact point university/economy)
- 25/01/1977 - Start of the "Bochumer Modell" (Bochum Model) of medical training in cooperation with hospital providers in the region, from 1998 "Klinikum der Ruhr-Universität Bochum" (Clinic of the Ruhr University Bochum)
- 20/08/1984 - New constitution – The university parliament is replaced by a "Konvent", the term"department" ("Abteilung") for the basic organizational unit of the university is changed to "faculty"
- 20/03/1998 - Foundation of the research and processing company "RUBITEC - Gesellschaft für Innovation und Technologie mbH" (RUBITEC - Society for Innovation and Technology)
- 13/04/1999 - Foundation of the “Akademie der Ruhr-Universität” (Academy of the Ruhr-Universität) (from May 2001 GmbH)
- 27/03/2002 - Entry into force of a new constitution – the previous "Konvent" as a central body is no longer in place, its competences are transferred to the Senate or extended Senate
- 02/26/2004 - Opening of the “Alfried Krupp Schülerlabor” (Alfried Krupp School Student Laboratory)
- 08/11/2005 - Establishment of the “Zentrum für Fremdsprachenausbildung” (Center for Foreign Language Education)
- 01/11/2006 - Start of the campus-wide graduate school "Ruhr-University Research School"
- 01/01/2007 - Transfer of the “Landesspracheninstitut” (State Language Institute” to the RUB
- 12/03/2007 - Foundation of the “Universitätsallianz Metropole Ruhr” (“Research Alliance Ruhr”) by the universities of Bochum, Dortmund and Duisburg-Essen
- 25/10/2007 - Adoption of a new constitution by the Senate - RUB receives an externally staffed University Council and, as a further body, the Faculty Conference.
- 12/01/2009 - Establishment of the first three interdisciplinary Research Departments - With the establishment of three more in 2009/2010, the original planning of the future concept "RUB Research Campus" is implemented
- 01/09/2010 - Foundation of the "Professional School of Education"